INDUCIBLE NITRIC OXIDE SYNTHASE IMMUNOREACTIVITY IN DENTURE INDUCED FIBROUS INFLAMMATORY HYPERPLASIA AND HEALTHY ORAL MUCOSA: AN IMMUNOHISTOCHEMICAL STUDY


Kocaelli H. , Keklikoglu N.

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, vol.23, no.3, pp.1378-1382, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.1080/13102818.2009.10817674
  • Journal Name: BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.1378-1382
  • Keywords: inducible nitric oxide synthase, iNOS, denture induced fibrous inflammatory hyperplasia, healthy oral mucosa, SQUAMOUS-CELL CARCINOMA, GAMMA-PRODUCING CELLS, HEAT-SHOCK PROTEINS, RADICULAR CYSTS, EXPRESSION, LESIONS, DENTISTRY, CYTOKINES, SEVERITY, DISEASE

Abstract

Excessive production of nitric oxide (NO) generated by inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of numerous inflammatory processes. The exact pathogenesis of denture-induced fibrous inflammatory hyperplasia (DIFIH) remains unclear The aim of this study was to assess iNOS expression in healthy oral mucosa (HOM) and DIFIH by immunohistochemical (IHC) method The expression of iNOS protein in HOM has been reported in numerous publications: particularly these tissues were used as a control group. However there are some conflicting results whether healthy oral tissues express iNOS. In this study performing IHC method, DIFIH (n = 26) and HOM (n = 28) in formalin-fixed, paraffin-embedded sections were evaluated in terms of iNOS expression. The statistical analysis showed that there were no significant differences between DIFIH and HOM regarding iNOS immunoreactivity (p>0.05). The results in this study indicate that iNOS does not have a determining role in pathogenesis of DIFIH. The constitutive iNOS expression in HOM under physiological conditions needs to be further evaluated