Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis
Journal of Neuroimmunology, cilt.398, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 398
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.jneuroim.2024.578489
- Dergi Adı: Journal of Neuroimmunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Psycinfo, Veterinary Science Database
- Anahtar Kelimeler: Innate lymphoid cell, Innate lymphoid cell plasticity, Interleukin-10, Multiple sclerosis, Retinoic acid
- İstanbul Üniversitesi Adresli: Evet
Özet
This study investigates the frequency and numbers of circulating helper innate lymphoid cells (ILCs) in untreated relapsing-remitting multiple sclerosis (RRMS) patients, focusing on intracellular IL-10 and CCR6 expressions under IL-2, IL-33, and retinoic acid (RA) stimulation in vitro and their associations with clinical features in RRMS. In RRMS patients, ILC1 levels were notably higher upon IL-2 + IL-33 + RA stimulation, while ILC2 levels, particularly the c-Kit+ ILC2 and CCR6+ ILC2 subsets, were significantly lower compared to unstimulated conditions. Additionally, IL-10+ ILC1 levels were elevated. The ratios of IL-10+ ILC1/ILC1, c-Kit+ ILC2/c-Kit− ILC2, and CCR6+ ILC2/ILC2 were associated with the progression index (PI) in RRMS patients.