Association between non-coding polymorphisms of HOPX gene and syncope in hypertrophic cardiomyopathy

Creative Commons License

Gulec C., Abaci N., Bayrak F., BAYRAK E. K., KAHVECI G., Guven C., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.14, sa.7, ss.617-624, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/akd.2014.4972
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.617-624
  • Anahtar Kelimeler: HOPX, hypertrophic cardiomyopathy, syncope, modifier gene, polymorphism, SERUM RESPONSE FACTOR, SQUAMOUS-CELL CARCINOMA, LEFT-VENTRICULAR HYPERTROPHY, HOMEODOMAIN PROTEIN, CARDIAC-HYPERTROPHY, HEART-FAILURE, SUDDEN-DEATH, LUNG-CANCER, EXPRESSION, MUTATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Homeodomain Only Protein X (HOPX) is an unusual homeodomain protein which regulates Serum Response Factor (SRF) dependent gene expression. Due to the regulatory role of HOPX on SRF activity and the regulatory role of SRF on cardiac hypertrophy, we aimed to investigate the relationship between HOPX gene variations and hypertrophic cardiomyopathy (HCM).