Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension

Samanci B., Samancı Y., Tuzun E., Altiokka-Uzun G., Ekizoglu E., Icoz S., ...More

CEPHALALGIA, vol.37, no.6, pp.525-531, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1177/0333102416650705
  • Journal Name: CEPHALALGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.525-531
  • Keywords: Adipokines, cytokines, idiopathic intracranial hypertension, nesfatin, obesity, TNF-ALPHA, CEREBROSPINAL-FLUID, INSULIN-RESISTANCE, SERUM LEPTIN, NESFATIN-1, EXPRESSION, IL-1-BETA, INDUCTION, BRAIN, IL-6
  • Istanbul University Affiliated: Yes

Abstract

Background: Although specific role players are currently unknown, contribution of inflammatory mediators has been suggested in the pathophysiology of idiopathic intracranial hypertension (IIH), which is a disease more prevalent in obese female individuals of childbearing age. We aimed to investigate the levels of adipokines and cytokines to demonstrate possible markers for inflammation that participate in IIH pathophysiology and their association with clinical features of IIH.