Nanocarriers Mediated Cutaneous Drug Delivery

Güngör S., Kahraman E.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.158, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 158
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.ejps.2020.105638
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Cutaneous delivery, topical delivery, skin delivery, follicular delivery, nanocarriers, dermatological skin diseases, SOLID LIPID NANOPARTICLES, MICROEMULSION-LOADED HYDROGEL, IN-VITRO, DERMAL DELIVERY, EX-VIVO, POLYMERIC NANOPARTICLES, COLLOIDAL CARRIERS, TOPICAL DELIVERY, GEL FORMULATIONS, SKIN PENETRATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

The cutaneous drug delivery represents an attractive option for the management of skin diseases. However, the skin has a very complex morphological structure, although the skin barrier is disrupted in some of dermatological diseases. Therefore, to safely overcome the skin barrier and to deliver drugs across the skin efficiently is still remain as a challenge in the management of dermatological diseases. The nanocarrier mediated cutaneous delivery appears to offer a hope to provide targeting potential of the drugs into specific sites of the skin with minimizing side effects. This review highlights the human structure and diseased skin barrier, and possible therapeutic outcomes of nanocarrier based drug delivery in the treatment of skin diseases due to their skin transport and follicular targeting mechanisms, and summarizes recent studies in which polymer, lipid and surfactant based nanocarriers of drugs used in the skin diseases.