The diagnostic value of macrophage migration inhibitory factor (MIF) in gastric cancer


Camlica H., Duranyildiz D., Oguz H., Oral E. N., Yasasever V.

PATHOLOGY & ONCOLOGY RESEARCH, vol.14, no.1, pp.79-83, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1007/s12253-008-9002-7
  • Journal Name: PATHOLOGY & ONCOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.79-83
  • Istanbul University Affiliated: Yes

Abstract

The present study was conducted to investigate the sensitivity, specificity, predictive values and accuracy of serum MIF, CEA, CA 19-9 levels and their various combinations in patients with gastric cancer. Study group consists of pathologically verified, gastric cancer (n=63) and apparently healthy controls (n=50). Serum MIF concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Serum values of patients were significantly higher than the controls (p=0.011). Diagnostic sensitivity and specificity, predictive values and accuracies were calculated for each marker and their various combinations. The best results were achieved with the marker combination of MIF-CEA-CA 19-9 and MIF-CEA combination. In our opinion, the combination of the markers MIF-CEA is a valuable diagnostic tool for gastric cancer.