Microbiota stratification identifies disease-specific alterations in neuro-Behcet's disease and multiple sclerosis

Oezguen N., Yalcinkaya N., Kucukali C. I., Dahdouli M., Hollister E. B., Luna R. A., ...More

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.37, no.6, pp.58-66, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2019
  • Journal Name: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.58-66
  • Keywords: Behcet's disease, multiple sclerosis, gut microbiota, 16S ribosomal RNA, dysbiosis, GUT MICROBIOTA, COMMENSAL BACTERIA, DENDRITIC CELLS, BDELLOVIBRIO, ENTEROTYPES
  • Istanbul University Affiliated: Yes

Abstract

Objective. Altered gut microbiota community dynamics are implicated in diverse human diseases including inflammatory disorders such as neuro-Behcet's disease (NBD) and multiple sclerosis (MS). Traditionally, microbiota communities are analysed uniformly across control and disease groups, but recent reports of subsample clustering indicate a potential need for analytical stratification. The objectives of this study are to analyse and compare faecal microbiota community signatures of ethno-geographical, age and gender matched adult healthy controls (HC), MS and NBD individuals.