Microbiota stratification identifies disease-specific alterations in neuro-Behcet's disease and multiple sclerosis

Oezguen N., Yalcinkaya N., Kucukali C. I., Dahdouli M., Hollister E. B., Luna R. A., ...Daha Fazla

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, cilt.37, sa.6, ss.58-66, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 6
  • Basım Tarihi: 2019
  • Dergi Adı: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.58-66
  • Anahtar Kelimeler: Behcet's disease, multiple sclerosis, gut microbiota, 16S ribosomal RNA, dysbiosis, GUT MICROBIOTA, COMMENSAL BACTERIA, DENDRITIC CELLS, BDELLOVIBRIO, ENTEROTYPES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Altered gut microbiota community dynamics are implicated in diverse human diseases including inflammatory disorders such as neuro-Behcet's disease (NBD) and multiple sclerosis (MS). Traditionally, microbiota communities are analysed uniformly across control and disease groups, but recent reports of subsample clustering indicate a potential need for analytical stratification. The objectives of this study are to analyse and compare faecal microbiota community signatures of ethno-geographical, age and gender matched adult healthy controls (HC), MS and NBD individuals.