Microbiota stratification identifies disease-specific alterations in neuro-Behcet's disease and multiple sclerosis


Oezguen N., Yalcinkaya N., Kucukali C. I. , Dahdouli M., Hollister E. B. , Luna R. A. , ...More

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.37, no.6, pp.58-66, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 6
  • Publication Date: 2019
  • Title of Journal : CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
  • Page Numbers: pp.58-66
  • Keywords: Behcet's disease, multiple sclerosis, gut microbiota, 16S ribosomal RNA, dysbiosis, GUT MICROBIOTA, COMMENSAL BACTERIA, DENDRITIC CELLS, BDELLOVIBRIO, ENTEROTYPES

Abstract

Objective. Altered gut microbiota community dynamics are implicated in diverse human diseases including inflammatory disorders such as neuro-Behcet's disease (NBD) and multiple sclerosis (MS). Traditionally, microbiota communities are analysed uniformly across control and disease groups, but recent reports of subsample clustering indicate a potential need for analytical stratification. The objectives of this study are to analyse and compare faecal microbiota community signatures of ethno-geographical, age and gender matched adult healthy controls (HC), MS and NBD individuals.