Reducing Aortic Barotrauma and Vascular Extracellular Matrix Degradation by Pacemaker-Mediated QRS Widening

SEZER M., Atici A., Coskun I., Cizgici Y., Ozcan A., UMMAN B., ...More

JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.9, no.10, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2020
  • Doi Number: 10.1161/jaha.119.014804
  • Journal Name: JOURNAL OF THE AMERICAN HEART ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Istanbul University Affiliated: Yes

Abstract

BACKGROUND: The extent of pressure-related damage might be related to acceleration rate of the applied pressure (peak dP/dt) in the vascular system. In this study, we sought to determine whether dP/dt applied to the aortic wall (aortic dP/dt) and in turn vascular extracellular matrix degradation can be mitigated via modulation of left ventricular (LV) contractility (LV dP/dt) by pacemaker-mediated desynchronization.