CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

ALLMAN W., QI H., SAINI S. S., LI J., Tuzun E., CHRISTADOSS P.

JOURNAL OF NEUROIMMUNOLOGY, vol.249, pp.1-7, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 249
  • Publication Date: 2012
  • Doi Number: 10.1016/j.jneuroim.2012.04.002
  • Journal Name: JOURNAL OF NEUROIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-7
  • Keywords: Myasthenia gravis, Experimental autoimmune myasthenia gravis, Autoimmunity, Lipopolysaccharide, CD4, ACETYLCHOLINE-RECEPTORS, AUTOIMMUNE-DISEASES, IMMUNE-RESPONSES, T-CELLS, MICE, COMPLEMENT, DIFFERENTIATION, INHIBITION, ANTIBODIES, INDUCTION
  • Istanbul University Affiliated: Yes

Abstract

The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle. (C) 2012 Elsevier B.V. All rights reserved.