CLINICAL SIGNIFICANCE OF SERUM HEPATOCYTE GROWTH FACTOR (HGF) AND ITS RECEPTOR CMET LEVELS IN COLORECTAL CANCER PATIENTS

KARABULUT M., ALIS H., GUNALDI M., AFSAR C. U., Karabulut S., KONES O., ...Daha Fazla

ACTA MEDICA MEDITERRANEA, cilt.32, sa.1, ss.179-187, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.19193/0393-6384_2016_1_28
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.179-187
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The cMET receptor tyrosine kinase and its ligand hepatocyte growth factor (HGF) regulate many signaling pathways involved in proliferation and cell motility, invasion and angiogenesis. Deregulation of HGF/cMET system by different biological mechanisms may contribute to the minor development in many types of cancers. Therefore, the present study was performed to investigate clinical significance of serum patterns of both HGF and cMET in colorectal cancer (CRC) patients.