TURKISH JOURNAL OF CHEMISTRY, cilt.37, sa.2, ss.171-181, 2013 (SCI-Expanded)
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Abstract: Simple and accurate spectrophotometric methods are presented for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors (statins), namely atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in pharmaceutical preparations. The methods are based on the reaction of drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as pi-acceptors to give highly colored complex species. All variables were studied in order to optimize the reaction conditions. Beer's law was obeyed in the concentration ranges 4-20 mu g mL(-1), 4-12 mu g mL(-1), 0.8-2.4 mu g mL(-1), 4-14 mu g mL(-1), and 2.5-20 mu g mL(-1) for atorvastatin, fluvastatin, pitavastatin, rosuvastatin, and simvastatin, respectively. The proposed methods were successfully applied to the pharmaceutical preparations without any interference from excipients. |
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