Enhanced susceptibility to autoxidation of VLDL plus LDL fractions in streptozotocin induced diabetic rats

Seckin S., Aykac-Toker G., Uysal M.

BIOCHEMICAL ARCHIVES, vol.15, no.2, pp.157-162, 1999 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 2
  • Publication Date: 1999
  • Journal Name: BIOCHEMICAL ARCHIVES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.157-162
  • Istanbul University Affiliated: Yes

Abstract

This study evaluated the effect of streptozotocin (STZ) induced diabetes on autoxidizability of VLDL + LDL fractions, plasma lipid peroxide and total thiol levels. Increased susceptibility to autoxidation of VLDL + LDL was observed following STZ treatment. Plasma lipid peroxide levels were found significantly higher in diabetic rats. However, plasma total thiol levels were observed decreased in experimental diabetes. In conclusion, the balance of prooxidant and antioxidant in plasma is disturbed by STZ treatment.