Urinary PGE(2) and PGF(2 alpha) levels and renal functions in preeclampsia

Vural P., Akgul C., CANBAZ M.

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.45, sa.4, ss.237-241, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1159/000009975
  • Dergi Adı: GYNECOLOGIC AND OBSTETRIC INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.237-241
  • İstanbul Üniversitesi Adresli: Evet

Özet

The role of prostaglandin E-2 (PGE(2)) and prostaglandin F-2 alpha (PGF(2 alpha)) in the pathogenesis of hypertension and altered renal functions, which are the main symptoms of preeclampsia, has gained importance. Serum and urine samples of 59 women (24 preeclamptic pregnant (PEP), 20 normotensive pregnant (NTP) and 15 nonpregnant) were investigated by means of prostaglandin levels and urea, creatinine and creatinine clearance values. PEP patients, when compared with NTP patients, show a significant decrease in PGE(2) and PGF(2 alpha) levels (p < 0.01 and p < 0.05, respectively) accompanied by changes in some parameters of renal function such as serum urea, creatinine and creatinine clearance. Although disorders in prostaglandin levels may be responsible for some renal pathologic changes, renal functional and morphologic alterations may also result in abnormal prostaglandin activity.