Effects of intravenous immunoglobulin therapy on behavior deficits and functions in sepsis model


Ozcan P. E. , Senturk E., Orhun G. , Gumru S., Arican N. , Orhan N. , ...More

ANNALS OF INTENSIVE CARE, vol.5, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2015
  • Doi Number: 10.1186/s13613-015-0062-z
  • Title of Journal : ANNALS OF INTENSIVE CARE
  • Keywords: Sepsis, Immunoglobulins, Cecal ligation and puncture, Plus maze test, Forced swimming test, Behavioral alteration, BLOOD-BRAIN-BARRIER, CECAL LIGATION, COGNITIVE IMPAIRMENT, RATS, MEMORY, INHIBITION, PARAMETERS, BREAKDOWN, REVERSES, STRESS

Abstract

Background: We aim to demonstrate behavioral alterations in a sepsis model using intravenous (IV) immunoglobulin G (IgG) and immunoglobulins enriched with IgA and IgM (IgGAM).