Effects of intravenous immunoglobulin therapy on behavior deficits and functions in sepsis model


Ozcan P. E., Senturk E., Orhun G., Gumru S., Arican N., Orhan N., ...More

ANNALS OF INTENSIVE CARE, vol.5, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2015
  • Doi Number: 10.1186/s13613-015-0062-z
  • Journal Name: ANNALS OF INTENSIVE CARE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Sepsis, Immunoglobulins, Cecal ligation and puncture, Plus maze test, Forced swimming test, Behavioral alteration, BLOOD-BRAIN-BARRIER, CECAL LIGATION, COGNITIVE IMPAIRMENT, RATS, MEMORY, INHIBITION, PARAMETERS, BREAKDOWN, REVERSES, STRESS
  • Istanbul University Affiliated: Yes

Abstract

Background: We aim to demonstrate behavioral alterations in a sepsis model using intravenous (IV) immunoglobulin G (IgG) and immunoglobulins enriched with IgA and IgM (IgGAM).