Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene increases the risk of developing Graves' disease

Dogru-Abbasoglu S., Vural P., Baki M., OZDERYA A., KARADAG B., Uysal M.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.20, sa.2, ss.366-369, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.intimp.2014.03.019
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.366-369
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Graves' disease (GD) arises due to complex interactions between genetic and environmental factors. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, thyroid follicular cell hyperplasia, and production of autoantibody in the thyroid gland of patients with GD.