MDR1 C3435T POLYMORPHISM: A PRELIMINARY STUDY ON ITS RELATIONSHIP WITH THE RISK OF COLORECTAL CANCER

Ozkara G., Yaylim I., Arikan S., İSBİR T., Aydogan H. Y.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, vol.84, no.4, pp.531-536, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.26650/iuitfd.2021.849990
  • Journal Name: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.531-536
  • Keywords: MDR1, C3435T, polymorphism, colorectal cancer, Turkish population, P-GLYCOPROTEIN, MULTIDRUG-RESISTANCE, FUNCTIONAL POLYMORPHISMS, GENETIC SUSCEPTIBILITY, TRANSPORTER GENE, ABCB1 GENE, EXPRESSION
  • Istanbul University Affiliated: Yes

Abstract

Objective: Colorectal carcinoma (CRC) is the third most frequent cancer in the world and a heterogenious disease which aroze from one or a combination of different genetic mechanisms. The multiple drug resistance-1 (MDR1) gene which encodes P-glycoprotein (P-gp) plays a part in the bioavailability of drugs and cell toxicity. In the current study, we aimed to investigate the possible relation between the MDR1 gene C3435T polymorphism and CRC risk in the Turkish population.