Cancer stem cells in oncology

Cetin I., Topcul M. R.

JOURNAL OF BUON, cilt.17, sa.4, ss.644-648, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 4
  • Basım Tarihi: 2012
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.644-648
  • Anahtar Kelimeler: cancer, cancer stem cells, CSC-targeted therapies, diagnosis, prognosis, therapeutic resistance, MARKERS, NICHE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Cancer stem cells (CSCs) possess several characteristics including self-renewal, pluripotency and tumorigenicity and constitute a rare population in a tumor mass. Because conventional cancer therapies can not kill CSCs, these cells are responsible for tumor relapse and metastasis. Currently, with advances in the identification of CSCs, the importance of these cells is increasing in the field of cancer diagnosis and prognosis. In addition, clarifying the mechanisms responsible for the maintenance of CSCs properties led to the development of CSC-targeted therapies.