Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells


Demirel G., Alpertunga B., Ozden S.

PHARMACEUTICAL BIOLOGY, vol.53, no.9, pp.1302-1310, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 9
  • Publication Date: 2015
  • Doi Number: 10.3109/13880209.2014.976714
  • Journal Name: PHARMACEUTICAL BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1302-1310
  • Keywords: Clone 9 cells, cytotoxicity, NRK-52E cells, TUMOR-SUPPRESSOR GENES, FUSARIUM MYCOTOXINS, SPHINGOLIPID METABOLISM, EPIGENETIC EVENTS, IN-VIVO, B-1, CANCER, MECHANISMS, HYPOMETHYLATION, DAMAGE
  • Istanbul University Affiliated: Yes

Abstract

Context: Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides (Sacc.) Nirenberg (Nectriaceae) mold that contaminates maize and other agricultural products. Although the effects of FB1 on sphingolipid metabolism are clear, little is known about early molecular changes associated with FB1 carcinogenicity.