Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells

Demirel G., Alpertunga B., Ozden S.

PHARMACEUTICAL BIOLOGY, cilt.53, sa.9, ss.1302-1310, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 53 Sayı: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/13880209.2014.976714
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1302-1310
  • Anahtar Kelimeler: Clone 9 cells, cytotoxicity, NRK-52E cells, TUMOR-SUPPRESSOR GENES, FUSARIUM MYCOTOXINS, SPHINGOLIPID METABOLISM, EPIGENETIC EVENTS, IN-VIVO, B-1, CANCER, MECHANISMS, HYPOMETHYLATION, DAMAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Context: Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium verticillioides (Sacc.) Nirenberg (Nectriaceae) mold that contaminates maize and other agricultural products. Although the effects of FB1 on sphingolipid metabolism are clear, little is known about early molecular changes associated with FB1 carcinogenicity.