Prophylthiouracil-induced cutaneous vasculitis


Yarman S., Sandalci O., Tanakol R., Azizlerli H., Oguz H., Alagol F.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, cilt.35, sa.7, ss.282-286, 1997 (SCI-Expanded) identifier identifier identifier

Özet

Cutaneous reactions to propylthiouracil and methimazole occur in 3% - 5% of adults. Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions. We report 3 patients who developed cutaneous vasculitis which is a rare and serious side-effect during antithyroid drug therapy. The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.