Growth Hormone/Insulin-Like Growth Factor-1 Axis as Related to Body Mass Index in Patients with Idiopathic Short Stature

Cengiz P., Bas F., Atalar F., Ucar A., Darendeliler F., Akan G., ...Daha Fazla

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.5, sa.1, ss.13-19, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4274/jcrpe.901
  • Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.13-19
  • Anahtar Kelimeler: Idiopathic short stature, insulin-like growth factor 1 (IGF-1), body mass index, IGF-1 receptor, IGF-binding protein 3 (IGFBP)-3, IGF-1 generation test, IGF-I, TURKISH CHILDREN, HORMONE INSENSITIVITY, PREPUBERTAL CHILDREN, PUBERTAL CHANGES, SERUM-LEVELS, GH, REFERENCES, RECEPTOR, OBESITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Idiopathic short stature (ISS) is a heterogeneous disorder. An impairment of growth hormone (GH)/insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1 R) axis is postulated. To evaluate the somatotropic axis in relation to body mass index (BMI), serum IGF-1, IGF-binding protein-3 (IGFBP-3) and the expression of IGF-1 R genes in patients with ISS.