JOURNAL OF AOAC INTERNATIONAL, cilt.90, sa.2, ss.372-375, 2007 (SCI-Expanded)
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Author(s): Caglar, S (Caglar, Sena); Oztunc, A (Oztunc, Aysel) |
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Times Cited: 2 (from Web of Science) |
Cited References: 20 [ view related records ] Citation Map |
Abstract: A simple, rapid, and sensitive visible spectrophotometric method was developed, for the first time, for analysis of desloratadine (DE) in tablets. The method is based on the deep-blue colored TCNQ(center dot-) radical anion formed by interaction of the drug (n-donor) with 7,7,8,8-tetracyanoquinodimethane (TCNQ, pi-acceptor) in acetonitrile at ambient temperature. Optimum conditions for the reaction were investigated, absorbances were read at 843 nm, and the linearity range for concentrations of DE was found to be 1.5-13 mu g/mL. The reaction product remains stable up to 8 h when kept at room temperature in the dark. The developed method was validated and successfully applied to the determination of DE in tablets. The tablets were also analyzed with a column liquid chromatography method reported in literature. The results from both methods were statistically compared by t- and F-tests. No significant difference was found for the means and standard deviations at 95% confidence level. Accuracy was examined through recovery studies. Being very simple and reliable, the method can be recommended for routine quality control analysis of DE in tablets. |
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Document Type: Article |