Gender-modulated impact of apolipoprotein A5 gene (APOA5)-1131T > C and c.56C > G polymorphisms on lipids, dyslipidernia and metabolic syndrome in Turkish adults

Komurcu-Bayrak E., Onat A., Poda M., Humphries S. E., Palmen J., Guclu F., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.46, no.6, pp.778-784, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1515/cclm.2008.161
  • Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.778-784
  • Keywords: APOA5 polymorphisms, dyslipidemia, lipids, metabolic syndrome, Turkish population, PLASMA TRIGLYCERIDE LEVELS, CORONARY-HEART-DISEASE, CARDIOVASCULAR RISK, INSULIN-RESISTANCE, APOA5 GENE, ASSOCIATION, VARIANTS, MEN, POPULATION, DEFINITION
  • Istanbul University Affiliated: Yes

Abstract

Background: Apolipoprotein A5 (APOA5) gene polymorphisms are usually associated with plasma triglyceride levels. We evaluated the relationship of the APOA5 -1131T > C and c.56C > G polymorphisms [single nucleotide polymorphism (SNP)] with serum lipids, dyslipidemia [low high-density lipoprotein (HDL)/high triglyceride] and the risk for metabolic syndrome (IMS) in the Turkish Adult Risk Factor study.