The role of miRNAs targeting K-ras and APC genes in colorectal cancer

Yilmaz N., Yilmaz U., Tanbek K., Arikan S., Aksakal N., Zeybek U., ...More

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, no.8, pp.554-557, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 8
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_092
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.554-557
  • Keywords: colorectal, cancer, miRNA, APC, K-ras, ADENOMATOUS-POLYPOSIS-COLI, TUMOR-SUPPRESSOR GENE, PROMOTES, CELL, MICRORNAS, MIR-217, DIFFERENTIATION, PROLIFERATION, BIOMARKERS, EXPRESSION
  • Istanbul University Affiliated: Yes

Abstract

OBJECTIVES: The occurrence of abnormal expression patterns in different types of cancer suggests that micro RNAs (miRNAs) may play an important role in tumorigenesis. The aim of this study was to examine the expression levels of miRNAs known to be associated with the regulation of the expression levels of the APC and K-ras, which are important in the development of colorectal cancer (CRC).