DETERMINATION OF SOME SELECTED PHARMACEUTICALS IN MARINE BIOTA: A CASE STUDY IN THE ISTANBUL METROPOLITAN AREA, TURKEY

Korkmaz N., Caglar N. B., Aksu A.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.30, sa.9, ss.10825-10835, 2021 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 9
  • Basım Tarihi: 2021
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Environment Index, Geobase, Greenfile, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.10825-10835
  • Anahtar Kelimeler: Pharmaceuticals, Fish species, Mytilus galloprovinc alis, Ulva laccuta, Golden Horn Estuary, Istanbul, ENDOCRINE DISRUPTING CHEMICALS, PERSONAL CARE PRODUCTS, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, TROPHIC MAGNIFICATION, SURFACE-WATER, GOLDEN HORN, BIOACCUMULATION, DICLOFENAC, FISH, 17-ALPHA-ETHINYLESTRADIOL
  • İstanbul Üniversitesi Adresli: Evet

Özet

This paper presents data on eleven pharmaceuticals of different classes (nonsteroidal anti-inflammatory drugs, blood lipid regulators, antiepileptics and hormones) in biota (mussels, macroalgae, fish muscle tissue) from the Golden Hone Estuary, Turkey. An ultrasonic extraction method was used to extract pharmaceuticals from the biota. The solid phase extraction (SPE) method was used for cleanup. H igh-pe rfo nuance liquid chromatography (HPLC) with a DAD detector was used to quantify the pharmaceuticals. All target compounds were detected in at least one of the samples. Gemfibrozil (56-9135 ng/g) was the most frequently detected compound in all biota samples. Five pharmaceuticals were detected in the macroalgae samples at a maximum concentration of 7221 ng/g for gemfibrozil. Additionally, nine of the pharmaceutical compounds were detected in several or all of the seven fish species. The highest concentration of 17ct-ethinylestradiol detected in.Vlullus barbatus was 1258 ng/g. The concentrations of diclofenac (4694 ng/g), naproxen (1570 ng/g), ibuprofen (5098 ng/g), 1713-estradiol (2364 ng/g), clofibric acid (1296 ng/g), and gernfibrozil (9135 ng/g) were considerably higher in mussels than in other biota species. The accumulation potential of pharmaceutical compounds was higher in mussels than in other biota species.