Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism.

Hatemi, Ali; Gulec, Çağrı; Cine, Naci; Vural, Burçak; Hatirnaz, Özden; Sayitoglu, Müge; Oztunc, Funda; Saltik, Levent; Kansiz, Erhan; Unaltuna, Nihan

doi:10.5152/akd.2011.083

Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism.

Atıf İçin Kopyala

Hatemi A. C., Gulec Ç., Cine N., Vural B., Hatirnaz O., Sayitoglu M., ...Daha Fazla

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, cilt.11, sa.4, ss.319-28, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 11 Sayı: 4
Basım Tarihi: 2011
Doi Numarası: 10.5152/akd.2011.083
Dergi Adı: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.319-28
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Atrial isomerism is a congenital disorder, which is characterized by lateralization defects in normally asymmetrical developing organs like the heart. Atrial isomerism is supposed to be caused by molecular defects during early development. The NKX2-5 is a cardiac specific transcription factor, which initiates and regulates downstream transcriptional cascades of cardiogenesis. The HAND1 is another transcription factor expressed in the heart, and it is characterized by an asymmetrical pattern of expression. In this study, we aimed to test whether mutations in NKX2-5 and HAND1 genes play a role in the etiology of atrial isomerism.