Is there any correlation between TNF-related adoptosis-inducing ligand (TRAIL) genetic variants and breast cancer?

Yildiz Y., Yaylim-Eraltan I., Arıkan S., Ergen H. A., Kucucuk S., Isbir T.

ARCHIVES OF MEDICAL SCIENCE, vol.6, no.6, pp.932-936, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 6
  • Publication Date: 2010
  • Doi Number: 10.5114/aoms.2010.19304
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.932-936
  • Keywords: TRAIL, breast cancer, susceptibility, prognosis, polymorphism, INDUCED APOPTOSIS, MULTIPLE-SCLEROSIS, RECEPTOR FAMILY, CELL-LINES, IDENTIFICATION, CHEMOTHERAPY, POLYMORPHISM, MEMBER, APO2L/TRAIL, CLONING
  • Istanbul University Affiliated: Yes

Abstract

Introduction: TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand and also a member of the TNF superfamily. We aimed to investigate the possible relationship between TRAIL and breast cancer. Here, we report the results of the first association study on genetic variation in the TRAIL gene and its effect on breast cancer susceptibility and prognosis.