Acquired FVIII and FIX Inhibitors after Pregnancy: A Case Report.

Kose M., Bakkaloglu O. K., Amikishiyev S., Akpinar T. S., Saracoglu B., Akcan T., ...More

Acta haematologica, vol.136, no.4, pp.229-232, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1159/000445706
  • Journal Name: Acta haematologica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.229-232
  • Keywords: Acquired hemophilia, Autoantibodies, FVIII and FIX inhibitors, FACTOR-VIII, HEMOPHILIA-A, FACTOR-IX, THERAPY, PATIENT
  • Istanbul University Affiliated: Yes


Acquired hemophilia is a relatively rare clinical presentation, and most cases present with acquired FVIII inhibitor. The co-occurrence of inhibitors to multiple coagulation factors is uncommon. These autoantibodies may induce spontaneous life-threatening bleeding in patients who have had no previous bleeding disorder. Herein, we present a patient with postpartum acquired FVIII and FIX inhibitors who developed intramuscular hematoma and hemothorax during follow-up. She was then treated with activated prothrombin complex concentrate and methylprednisolone. (C) 2016 S. Karger AG, Basel