Journal of neuroinflammation, vol.12, pp.231, 2015 (Journal Indexed in SCI Expanded)
Article / Article
Title of Journal :
Journal of neuroinflammation
Myasthenia gravis, Muscle-specific kinase, Mesenchymal stem cells, Dendritic cells, Autoimmunity, AUTOIMMUNE MYASTHENIA-GRAVIS, TYROSINE KINASE MUSK, BONE-MARROW, CLINICAL-APPLICATIONS, SUPPRESSION, EXPRESSION, GAMMA
Background: Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction (NMJ), mostly associated with acetylcholine receptor (AChR) antibodies. Around 5-10 % of MG patients show antibodies to muscle-specific tyrosine kinase (MuSK). Mesenchymal stem cell (MSC) administration has been shown to ameliorate muscle weakness in the experimental autoimmune myasthenia gravis (EAMG) model induced by AChR immunization.