Endothelial constitutive nitric oxide synthase, angiotensin converting enzyme, angiotensin II type 1 receptor gene polymorphisms and endothelial functions in healthy individuals.

Akpinar T. S., Ozkok A., Kose M., Atas R., Sumnu A., Bakkaloglu O. K., ...Daha Fazla

European review for medical and pharmacological sciences, cilt.18, sa.1, ss.39-45, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2014
  • Dergi Adı: European review for medical and pharmacological sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.39-45
  • Anahtar Kelimeler: Angiotensin converting enzyme polymorphism, Angiotensin II type 1 receptor polymorphisms, Endothelial constitutive nitric oxide synthase polymorphism, Endothelial dysfunction, Endothelium dependent vasodilatation, Endothelium independent vasodilatation, CORONARY-ARTERY-DISEASE, DEPENDENT VASODILATION, MEDIATED VASODILATION, HYPERTENSIVE PATIENTS, DYSFUNCTION, RISK, ATHEROSCLEROSIS, INHIBITION, ANTAGONISM, ULTRASOUND
  • İstanbul Üniversitesi Adresli: Evet

Özet

INTRODUCTION: Endothelial dysfunction is recognized as an early and initiating event in the pathogenesis of coronary artery disease. Gene polymorphisms of endothelial constitutive nitric oxide synthase (ecNOS), angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (AT1R) have been found to be associated with atherosclerosis. We aimed to investigate the possible effects of ecNOS, ACE and AT1R gene polymorphisms on endothelial functions in healthy population.