PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population

Nursal A. F., Aydin P. C., Uysal M. A., Pehlivan M., Oyac Y., PEHLİVAN S.

ARCHIVES OF CLINICAL PSYCHIATRY, cilt.47, sa.3, ss.71-74, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1590/0101-60830000000235
  • Dergi Adı: ARCHIVES OF CLINICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.71-74
  • Anahtar Kelimeler: Substance use disorder, smoking status, Per3, VNTR, PCR, SLEEP PROBLEMS, SUBSTANCE USE, DIURNAL PREFERENCE, CIGARETTE-SMOKING, POLYMORPHISM, ASSOCIATION, CLOCK, GENE, DISTURBANCE, DEPENDENCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population.