Akademik Veri Yönetim Sistemi
Türkiye Organ Nakli Kuruluşları Koordinasyon Derneği Xı. Kongresi, Trabzon, Türkiye, 13 - 15 Ekim 2016, ss.92
THE RELEVANCE OF FLOW CYTOMETRIC AUTO CROSSMATCH TO THE
POST TRANSPLANT COURSE OF KIDNEY TRANSPLANT RECIPIENTS
Demir E. 1, Yegit O.O. 1, Erol A. 2, Usta Akgul S. 2, Caliskan B. 3, Caliskan Y. 1, Turkmen A.1, Oguz
Savran F. 2, Sever M.Ş. 1
Istanbul Faculty of Medicine, Istanbul University, Division of Nephrology, Department of
Internal Medicine, Istanbul-Turkey 1 Istanbul Faculty of Medicine, Istanbul University,
Department of Medical Biology, Istanbul-Turkey 2 Haseki Training and Research Hospital,
Pediatric Infectious Diseases Unit, Istanbul-Turkey 3
Introduction and aims
The aim of this study was to investigate the effects of flow cytometric auto-crossmatch test on
post-tx events of kidney tx recipients.
Methods
A total of thirty-five patients underwent living renal tx with positive flow cytometric autocross
match test were evaluated. The records of these 35 patients were compared to a control
group including 57 living kidney tx recipients with negative flow cytometric auto-cross match
test [36 (63%) male, mean age:38±11 year]. Post-tx events of the study groups were
evaluated.
Results
The study and control groups were matched with regard to age, gender and time of tx
(p=0.206, p=0.762 and p=0.205, respectively). During the median post-tx follow up of 53.5
(IQR 26.7-83.7) months biopsy confirmed chronic antibody mediated rejection (CAMR) was
developed in 11.4% (n=4) of the patient and 1.8% (n=1) of the control groups (p=0.047). The
patients in the study group had a significantly higher rate of recurrent glomerulonephritis
(GN) after kidney tx (5/11, 46%) compared to control group (1/14, 7.1%) (p=0.026). There
were no differences regarding first (1.24±0.20 vs 1.32±0.37) and 12th months (1.25±0.37 vs
1.27±0.67) serum creatinine levels between study and control groups (p=0.286 and p=0.910,
respectively). The rate of new onset diabetes after tx (NODAT) was significantly higher in
study group (n=7, 20%) compared to controls (n=0, 0%) (p<0.001).
Conslusions
The findings of this study suggest a potential role of auto-antibody causing positive
autocrossmatch
test, meanwhile increasing the risk of CAMR, recurrent GN and NODAT. Further
studies are required to clarify this issue.