FLAVONOIDS AND BIOLOGICAL ACTIVITIES OF CENTAUREA NERIMANIAE S. KULTUR


Melikoglu G., Ozsoy N., Yilmaz-Ozden T., Erbay M. S., Anil S., Celik B. O., ...More

FARMACIA, vol.66, pp.1070-1075, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 66
  • Publication Date: 2018
  • Doi Number: 10.31925/farmacia.2018.6.22
  • Journal Name: FARMACIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1070-1075
  • Keywords: Centaurea nerimaniae S. Kultur, flavonoids, antioxidant, anti-acetylcholinesterase, anti-inflammatory, antimicrobial activity, ANTIMICROBIAL ACTIVITIES, ANTIOXIDANT PROPERTIES, ESSENTIAL OIL, EXTRACTS, ASTERACEAE, ANATOLIA
  • Istanbul University Affiliated: Yes

Abstract

Centaurea nerimaniae S. Kultur, an endemic species from the Turkish flora, distributed in south Anatolia (Icel Province) was investigated for its flavonoids and in vitro antioxidant, anti-cholinergic, anti-inflammatory and antibacterial activities. The phytochemical investigation of the plant led to the isolation of five flavonoids, identified as cirsimaritin, hispidulin, apigenin, isokaempferide and apigenin 7-O-glucoside. In addition to its ability to inhibit AChE and lipid peroxidation, induced by Fe3+/ascorbate system, scavenge DPPH radicals, and to reduce Fe3+ to Fe2+, the extract showed strong COX-1 and COX-2 inhibitory and antimicrobial activities, suggesting that this plant could act as an antioxidant and anti-inflammatory agent against disorders, associated with oxidative damage, as well as an effective phytotherapeutic agent against some fungal and bacterial diseases.