Akademik Veri Yönetim Sistemi
20th Annual Congress of International Drug Discovery Science and Technology - Japan 2024 (IDDST-Japan 2024), Osaka, Japonya, 22 - 24 Mayıs 2024, ss.10
Insomnia is a condition defined by difficulties initiating and maintaining quality sleep despite plenty sleep chances, which disrupts daytime activities. Disrupting the sleep-wake cycle or having inadequate sleep may have negative effects on the central nervous system. Prolonged sleep deficit leads to impairment in metabolism, immune system and other regulatory systems. It is treated with the medicine like benzodiazepine receptor agonists, barbiturates, tricyclic antidepressants. Due to their adverse effects, herbal medicines, homeopathic remedies, and different nutritional supplements are also preferred. Studies, including those conducted by our research group, have has demonstrated that the rhizomes and roots of Valeriana species contain effective compounds on the central nervous system, such as valepotriates. Due to these compounds, Valeriana officinalis and Valeriana jatamansi can be used medicinally to treat anxiety, depression, and insomnia. Although they are preferred for therapeutic uses, recent research suggests that other Valeriana species may have comparable and promising potential. The purpose of this study is to assess the potential of other Valeriana species in the treatment of sleep disorders by evaluating research on their ethnobotanical use, chemical compositions, and bioactivities, as well as to determine whether they can be used safely against insomnia instead of medicinal species.