Local aromatase activity alterations in breast cancer tissues: A potential way of decision support for clinicians.

Tuzuner M., Ozturk T., Ilvan S., Turna H., Yurdun T., Yilmaz-Aydogan H., ...Daha Fazla

Experimental and molecular pathology, cilt.118, ss.104574, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 118
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.yexmp.2020.104574
  • Dergi Adı: Experimental and molecular pathology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.104574
  • Anahtar Kelimeler: Breast cancer, Tumor microenvironment, Aromatase, Estrogens, Mass spectrometry
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and aims: It is becoming evident that local estrogen exposure is important in postmenopausal breast cancer patients. The microenvironment is established by breast stromal cells based on communication with tumor cells that is essential to cancer development, invasion, and metastasis. Here we investigated aromatase activity levels in both tumor and matched stromal tissues by showing their impact on the manufacturing of local estrogen and tumor progression in cases of invasive ductal carcinoma (IDC).