Akademik Veri Yönetim Sistemi
Ulusal Travma ve Acil Cerrahi Dergisi, cilt.31, sa.5, ss.431-437, 2025 (SCI-Expanded)
BACKGROUND: This experimental study aimed to investigate the effects of enterally administered daidzein on colon anastomosis in a rat model of colitis. METHODS: A total of 48 male Wistar albino rats were used and randomly divided into eight groups of six rats each. Colitis was induced by administering either water or a 4% acetic acid solution via rectal catheter, depending on the group. On day 5, all rats un- derwent segmental colon resection followed by end-to-end colo-colonic anastomosis. Daidzein was administered orally to four of the groups after the procedure. Relaparotomy was performed on postoperative days 3 and 7, and the anastomosed colon segments were resected. Anastomotic bursting pressure and tissue levels of superoxide dismutase, glutathione peroxidase, and hydroxyproline were measured. Histopathological damage scores were also evaluated. RESULTS: In both early and late postoperative periods, administration of daidzein did not result in a statistically significant improve- ment in anastomotic safety, based on hydroxyproline levels and bursting pressure, in either colitis or non-colitis groups (p>0.05). Daidzein also did not show a reducing effect on superoxide dismutase and glutathione peroxidase levels in anastomotic tissue (p>0.05). However, in the late postoperative period, daidzein showed a favorable effect on histopathological damage scores in non-colitis groups. CONCLUSION: Enteral administration of daidzein in rats with experimentally induced colitis did not demonstrate a statistically significant benefit in terms of colon anastomosis healing.