Association of SUMO4 M55V and-94Ins/Del Gene Variants with Type-2 Diabetes


Sozen S., Horozoglu C., Bireller E. S., KARAALI Z., Cakmakoglu B.

IN VIVO, cilt.28, sa.5, ss.919-923, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 5
  • Basım Tarihi: 2014
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.919-923
  • Anahtar Kelimeler: NFKB1, polymorphism, SUMO4, type 2 diabetes, CHROMOSOME 6Q, MET55VAL POLYMORPHISM, INSULIN-RESISTANCE, MELLITUS, SUSCEPTIBILITY, SWEDISH, LOCUS, POPULATIONS, ACTIVATION, FAMILIES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: There are two different types of diabetes mellitus, type 1 and type 2, with still unclear molecular mechanisms. In the present study, we aimed to investigate the role of small ubiquitin-like modifier 4 (SUMO4) M55V and nuclear factor kappa B1 (NFKB1)-94del/ins in type-2 diabetes mellitus. Materials and Methods: We analyzed SUMO4 M55V and NFKB1-94del/ins variants in 104 patients with type-2 diabetes and 124 healthy controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. Results: The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control group; however, no efficiency results were found related to NFKB1-94del/ins polymorphism. Conclusion: It was found that SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility. This preliminary study showed that the distribution of SUMO4 M55V and type-2 diabetes mellitus in Turkish patients may form the basis of future research.