Transdermal films of metoclopramide hydrochloride with terpenes as penetration enhancers: Design, characterization, in vitroevaluation and ATR-FTIR spectroscopic investigation on excised pig skin


ERDAL M. S. , SAĞIRLI A. O. , ERGİNER Y.

Asian Chemistry Letters, vol.16, no.1, pp.67-78, 2011 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2011
  • Journal Name: Asian Chemistry Letters
  • Page Numbers: pp.67-78

Abstract

The aim of this study was to develop novel transdermal films of metoclopramide hydrochloride (MTC) with sodium alginate as matrix agent to investigate the influence of various terpenes on in vitro release of MTC from transdermal films. ATR-FTIR studies on excised pig skin were performed in order to evaluate the effect of terpenes (nerolidol, eucalyptol, dl-limonene or terpinolene) on barrier function of skin. Transdermal filmsof MTC prepared using sodium alginate as matrix agent had the good physicochemical and adhesive properties. In vitrorelease data indicated that MTC had highest drug release ratefrom the films containing terpinolene as permeation enhancer. On the other hand, the mixtures containing limonene as terpene, produced greater decrease in peak heights and areas of asymmetric and symmetric stretching vibrations in comparison to the untreated skin, suggesting an overall extraction of the stratum corneum lipids. Future studies will be focusing on in vitro/in vivopermeation studies to optimize permeation of drug from the formulations.
Keywors: Metoclopramide hydrochloride, sodium alginate, transdermal film, terpenes, ATR-FTIR.