Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAF<sup>V600E</sup> Mutation.


Poyrazoglu S., Bundak R., Bas F., Yegen G., Sanli Y., Darendeliler F. F.

Journal of clinical research in pediatric endocrinology, vol.9, no.3, pp.185-193, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.4274/jcrpe.3873
  • Journal Name: Journal of clinical research in pediatric endocrinology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.185-193
  • Keywords: Children, pediatric thyroid cancer, papillary thyroid cancer, puberty, BRAF mutation, BRAF MUTATION, HIGH PREVALENCE, YOUNG-PATIENTS, CARCINOMA, CHILDHOOD, RECURRENCE, MICROCARCINOMA, ADOLESCENTS, RADIOIODINE, EXPERIENCE
  • Istanbul University Affiliated: Yes

Abstract

Objective: Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients with emphasis on the pubertal status and also to investigate the association of BRAF(V600E) mutation with disease characteristics.