Therapeutic modalities and clinical outcomes in a large cohort with LRBA deficiency and CTLA4 insufficiency

Taghizade, Nigar; Babayeva, Royala; Kara, Altan; Karakus, Ibrahim; Catak, Mehmet; Bulutoglu, Alper; HASKOLOĞLU, ZEHRA; Akay Haci, Idil; Tunakan Dalgic, Ceyda; Karabiber, Esra; Bilgic Eltan, Sevgi; Yorgun Altunbas, Melek; Sefer, Asena; Sezer, Ahmet; Kokcu Karadag, Şefika; Arik, Elif; Karali, Zuhal; Ozhan Kont, Aylin; Tuzer, Can; Karaman, Sait; Mersin, Selver; Kasap, Nurhan; Celik, Enes; Kocacik Uygun, Dilara; Aydemir, Sezin; Kiykim, Ayça; Aydogmus, Cigdem; Ozek Yucel, Esra; Celmeli, Fatih; Karatay, Emrah; Bozkurtlar, Emine; Demir, Semra; Metin, Ayse; Karaca, Neslihan; Kutukculer, Necil; Aksu, Guzide; Guner, Sukru; Keles, Sevgi; Reisli, Ismail; Kendir Demirkol, Yasemin; Arikoglu, Tugba; Gulez, Nesrin; Genel, Ferah; Kilic, Sara; Aytekin, Caner; Keskin, Ozlem; Yildiran, Alisan; Ozcan, Dilek; Altintas, Derya; Ardeniz, Fatma; Dogu, Esin; Ikinciogullari, Kamile; Karakoc-Aydiner, Elif; Ozen, Ahmet; Baris, Safa

doi:10.1016/j.jaci.2023.08.004

Therapeutic modalities and clinical outcomes in a large cohort with LRBA deficiency and CTLA4 insufficiency

Taghizade N., Babayeva R., Kara A., Karakus I. S., Catak M. C., Bulutoglu A., ...Daha Fazla

Journal of Allergy and Clinical Immunology, cilt.152, sa.6, ss.1634-1645, 2023 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 152 Sayı: 6
Basım Tarihi: 2023
Doi Numarası: 10.1016/j.jaci.2023.08.004
Dergi Adı: Journal of Allergy and Clinical Immunology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Food Science & Technology Abstracts, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.1634-1645
Anahtar Kelimeler: abatacept, cytotoxic T-lymphocyte-associated antigen-4, hematopoietic stem cell transplantation, immune dysregulation, Inborn errors of immunity, LPS-responsive beige-like anchor, natural history
İstanbul Üniversitesi Adresli: Evet

Özet

Background: LPS-responsive beige-like anchor (LRBA) deficiency (LRBA–/–) and cytotoxic T-lymphocyte–associated antigen-4 (CTLA4) insufficiency (CTLA4+/–) are mechanistically overlapped diseases presenting with recurrent infections and autoimmunity. The effectiveness of different treatment regimens remains unknown. Objective: Our aim was to determine the comparative efficacy and long-term outcome of therapy with immunosuppressants, CTLA4-immunoglobulin (abatacept), and hematopoietic stem cell transplantation (HSCT) in a single-country multicenter cohort of 98 patients with a 5-year median follow-up. Methods: The 98 patients (63 LRBA–/– and 35 CTLA4+/–) were followed and evaluated at baseline and every 6 months for clinical manifestations and response to the respective therapies. Results: The LRBA–/– patients exhibited a more severe disease course than did the CTLA4+/– patients, requiring more immunosuppressants, abatacept, and HSCT to control their symptoms. Among the 58 patients who received abatacept as either a primary or rescue therapy, sustained complete control was achieved in 46 (79.3%) without severe side effects. In contrast, most patients who received immunosuppressants as primary therapy (n = 61) showed either partial or no disease control (72.1%), necessitating additional immunosuppressants, abatacept, or transplantation. Patients with partial or no response to abatacept (n = 12) had longer disease activity before abatacept therapy, with higher organ involvement and poorer disease outcomes than those with a complete response. HSCT was performed in 14 LRBA–/– patients; 9 patients (64.2%) showed complete remission, and 3 (21.3%) continued to receive immunosuppressants after transplantation. HSCT and abatacept therapy gave rise to similar probabilities of survival. Conclusions: Abatacept is superior to immunosuppressants in controlling disease manifestations over the long term, especially when started early, and it may provide a safe and effective therapeutic alternative to transplantation.