The effect of chronic stress on hepatic and gastric lipid peroxidation in long-term depletion of glutathione in rats

Seckin S., ALPTEKIN N., DogruAbbasoglu S., KocakToker N., TOKER G., Uysal M. M.

PHARMACOLOGICAL RESEARCH, no.1, pp.55-57, 1997 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 1997
  • Doi Number: 10.1006/phrs.1997.0204
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.55-57
  • Istanbul University Affiliated: Yes


The effect of chronic stress (immobilization and cold) on hepatic and gastric thiobarbituric acid reactive substances (TEARS) and vitamin C levels were investigated in rats having long-term depletion of glutathione (GSH) by applying buthionine sulfoximine (BSO). GSH and vitamin C levels decreased and TEARS levels increased in the liver and stomach of rats subjected to stress. Long-term BSO administration along with stress caused no additional changes in these parameters. These results may indicate that long-term glutathione depletion did not potentiate stress-induced hepatic and gastric lipid peroxidation. (C) 1997 The Italian Pharmacological Society.