Cu(ii) salen and 1,2,4-triazole complexes from thiosemicarbazone: synthesis, physicochemical and structural properties and cytotoxic activities

AVCU ALTIPARMAK E., Erdemir G., ÖZDEMİR N., Kuruca S. E., BAL DEMİRCİ T.

NEW JOURNAL OF CHEMISTRY, cilt.44, sa.14, ss.5333-5342, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 14
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1039/c9nj04455h
  • Dergi Adı: NEW JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, Chimica, EMBASE, DIALNET
  • Sayfa Sayıları: ss.5333-5342
  • İstanbul Üniversitesi Adresli: Evet

Özet

A triazole complex of copper(ii) containing ethylenediamine as a coligand was synthesized using salicylaldehydethiosemicarbazone in the presence of CuCl2. Also, a dinuclear copper(ii) complex was synthesized using the same reagents; however, the order of their addition was different. The structures of these two complexes were characterized via elemental analysis, IR, H-1-NMR, and UV-Vis spectroscopy and mass spectrometry (MS). Furthermore, the molecular structures of complexes I and II were determined via single-crystal X-ray structure analysis. The copper(ii) ion has a distorted square-pyramidal geometry in complex I and a distorted square-planar geometry in complex II. Their fragmentation products were investigated in detail by ESI-MS. Finally, the cytotoxic effects of both complexes were evaluated in MDA-MB-231, MCF-7 and 3T3 fibroblast cell lines via the MTT assay and flow cytometry.