HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey

Koksal M. O., Beka H., LUBKE N., VERHEYEN J., Eraksoy H., Cagatay A., ...Daha Fazla

MEDICAL MICROBIOLOGY AND IMMUNOLOGY, cilt.204, sa.4, ss.551-555, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 204 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s00430-015-0419-9
  • Dergi Adı: MEDICAL MICROBIOLOGY AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.551-555
  • Anahtar Kelimeler: HIV-1 epidemiology in Turkey, Antiretroviral drug resistance, REVERSE-TRANSCRIPTASE, ANTIRETROVIRAL THERAPY, HIV-1-INFECTED PATIENTS, PROTEASE INHIBITORS, WILD-TYPE, MUTATIONS, SUSCEPTIBILITY, PATTERNS, NAIVE, GENE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection. The aim of the study was to determine the prevalence of HIV-1 drug resistance in 50 heterosexual patients from Istanbul. The most prevalent subtype was found to be subtype B (56.2 %). Resistance-associated mutations were found in 14 patients with 6/14 patients being therapy-experienced and 8/14 therapy naive at the time point of analysis. With increasing number of patients who require treatment and the rapid up-scaling of the antiretroviral therapy in Turkey, HIV-1 drug resistance testing is recommended before starting treatment in order to achieve better clinical outcomes.