NEPHROPATHY IN THE COURSE OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION - A CLINICOPATHOLOGICAL STUDY

BÜYÜKBABANİ N., DURRBACH A., CHAUVEAU D., TRAWALE J., VIARD J., DIOUF B., ...Daha Fazla

NEPHROLOGIE, cilt.14, sa.3, ss.143-149, 1993 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 1993
  • Dergi Adı: NEPHROLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.143-149
  • Anahtar Kelimeler: AIDS, HIV-1, FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, AZT
  • İstanbul Üniversitesi Adresli: Hayır

Özet

We report 16 patients with HIV1 infection with biopsy-proven renal involvement. Nine patients were caucasians and seven were blacks. There were 11 patients at stage II and 5 at stage IV of the HIV1 infection. Three patterns of histologic lesions were found: 6 patients, all blacks, with nephrotic syndrome and/or renal insufficiency had focal and segmental glomerulosclerosis (FSGS) with tubulo-interstitial lesions. In contrast, 6 patients, all caucasians, had various types of glomerulonephritis characterized by immunoglobulin and complement deposits; 3 of them were membranoproliferative glomerulonephritis (MPGN). The four remaining patients had predominant tubulo-interstitial lesions. In three patients who had FSGS, treatment by AZT induced temporary improvement of renal function and hemodialysis could be interrupted for a few months. The cure of infectious foci was followed by improvement in renal signs in two out of the 3 MPGN patients.