The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

Ozyigit, Leyla; Aktas, Esin; Senbas, Zarif; Ozturk, Ayse; Ozturk, Erman; Ergonul, Mehmet; Tabak, Levent; Ferhanoglu, Burhan; Cetiner, Mustafa; Deniz, Günnur

doi:10.1016/j.rmed.2019.06.020

The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

Ozyigit L. P., Aktas E., Senbas Z. A., Ozturk A. B., Ozturk E., Ergonul M. O., ...Daha Fazla

Respiratory medicine, cilt.155, ss.1-5, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 155
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.rmed.2019.06.020
Dergi Adı: Respiratory medicine
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1-5
Anahtar Kelimeler: Atopy, Bleomycin, Pulmonary toxicity, Bleomycin hydrolase, Amphiregulin, LUNG FIBROSIS, AMPHIREGULIN, EXPRESSION, RESPONSES, THERAPY, DISEASE, INJURY, TESTS
İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Bleomycin pulmonary toxicity (BPT) is a potentially life-threatening consequence of bleomycin usage in patients. An overproduction of epithelium-derived cytokines, habitually linked to allergic inflammation, has been recently revealed in experimental models of BPT.