The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

Ozyigit, Leyla; Aktas, Esin; Senbas, Zarif; Ozturk, Ayse; Ozturk, Erman; Ergonul, Mehmet; Tabak, Levent; Ferhanoglu, Burhan; Cetiner, Mustafa; Deniz, Günnur

doi:10.1016/j.rmed.2019.06.020

The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

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Ozyigit L. P., Aktas E., Senbas Z. A., Ozturk A. B., Ozturk E., Ergonul M. O., ...More

Respiratory medicine, vol.155, pp.1-5, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 155
Publication Date: 2019
Doi Number: 10.1016/j.rmed.2019.06.020
Journal Name: Respiratory medicine
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1-5
Keywords: Atopy, Bleomycin, Pulmonary toxicity, Bleomycin hydrolase, Amphiregulin, LUNG FIBROSIS, AMPHIREGULIN, EXPRESSION, RESPONSES, THERAPY, DISEASE, INJURY, TESTS
Istanbul University Affiliated: Yes

Abstract

Introduction: Bleomycin pulmonary toxicity (BPT) is a potentially life-threatening consequence of bleomycin usage in patients. An overproduction of epithelium-derived cytokines, habitually linked to allergic inflammation, has been recently revealed in experimental models of BPT.