The role of atopy in the pathogenesis of bleomycin pulmonary toxicity.

Ozyigit L. P., Aktas E., Senbas Z. A., Ozturk A. B., Ozturk E., Ergonul M. O., ...More

Respiratory medicine, vol.155, pp.1-5, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 155
  • Publication Date: 2019
  • Doi Number: 10.1016/j.rmed.2019.06.020
  • Journal Name: Respiratory medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-5
  • Keywords: Atopy, Bleomycin, Pulmonary toxicity, Bleomycin hydrolase, Amphiregulin, LUNG FIBROSIS, AMPHIREGULIN, EXPRESSION, RESPONSES, THERAPY, DISEASE, INJURY, TESTS
  • Istanbul University Affiliated: Yes


Introduction: Bleomycin pulmonary toxicity (BPT) is a potentially life-threatening consequence of bleomycin usage in patients. An overproduction of epithelium-derived cytokines, habitually linked to allergic inflammation, has been recently revealed in experimental models of BPT.