Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine.

Erguven M., Bilir A., Yazihan N., Ermis E., Sabanci A., Aktas E., ...Daha Fazla

Cancer cell international, cilt.11, sa.1, ss.18, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1186/1475-2867-11-18
  • Dergi Adı: Cancer cell international
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.18
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of combined noscapine (NOS) and imatinib mesylate (IM) on human GBM in vitro and the role of midkine (MK) in this new combination treatment.