Simvastatin improves spinal fusion in rats


Bostan B., GÜNEŞ T., AŞCI M., ŞEN C., Kelestemur M. H., Erdem M., ...Daha Fazla

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.45, sa.4, ss.270-275, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3944/aott.2011.2526
  • Dergi Adı: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.270-275
  • Anahtar Kelimeler: BMP, pseudoarthrosis, simvastatin, spinal fusion, statin, DEMINERALIZED BONE-MATRIX, STATINS, FRACTURE, MODEL, INHIBITION, GROWTH
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Statins stimulate bone formation by inducing the expression of bone morphogenetic proteins (BMP-2). The aim of our study was to investigate the effects of orally administered simvastatin on spinal fusion in rats.