Impact of fingolimod on CD4+T cell subset and cytokine profile of relapsing remitting multiple sclerosis patients

Kurtuncu M., Yilmaz V., Akcay H. I., Turkoglu R., Altunrende B., Cinar S., ...More

JOURNAL OF NEUROIMMUNOLOGY, vol.337, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jneuroim.2019.577065
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Fingolimod, Sphingosine-1-phosphate receptor, Cytokine, Chemokine, T cell, REGULATORY T-CELLS, ORAL FINGOLIMOD, INTERFERON, EXPRESSION, TH17
  • Istanbul University Affiliated: Yes


Fingolimod inhibits the egress of lymphocytes from lymphatic tissues and also directly affects their functions by modulation of the sphingosine-1 -phosphate receptor 1 (S1P1). Our aim was to evaluate the impact of fingolimod on diverse CD4+ T cell subsets, and cytokines.