Impact of fingolimod on CD4+T cell subset and cytokine profile of relapsing remitting multiple sclerosis patients


Kurtuncu M. , Yilmaz V. , Akcay H. I. , Turkoglu R., Altunrende B., Cinar S. , ...More

JOURNAL OF NEUROIMMUNOLOGY, vol.337, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337
  • Publication Date: 2019
  • Doi Number: 10.1016/j.jneuroim.2019.577065
  • Title of Journal : JOURNAL OF NEUROIMMUNOLOGY
  • Keywords: Fingolimod, Sphingosine-1-phosphate receptor, Cytokine, Chemokine, T cell, REGULATORY T-CELLS, ORAL FINGOLIMOD, INTERFERON, EXPRESSION, TH17

Abstract

Fingolimod inhibits the egress of lymphocytes from lymphatic tissues and also directly affects their functions by modulation of the sphingosine-1 -phosphate receptor 1 (S1P1). Our aim was to evaluate the impact of fingolimod on diverse CD4+ T cell subsets, and cytokines.