Correlations between physical activity and prognostic markers in patients with idiopathic pulmonary fibrosis

Oguz M. S., Bingol Z., Pihtili A., Akinci B., Arslan M. S., KURAN ASLAN G., ...Daha Fazla

Multidisciplinary Respiratory Medicine, cilt.20, 2025 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2025
  • Doi Numarası: 10.5826/mrm.2025.1021
  • Dergi Adı: Multidisciplinary Respiratory Medicine
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Anahtar Kelimeler: disease progression, dyspnea, fatigue, idiopathic pulmonary fibrosis, physical activity
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: In this study, we investigated the associations between physical activity parameters and prognostic factors in patients with idiopathic pulmonary fibrosis (IPF). Methods: Physical activity was measured in IPF patients using a SenseWear armband. Demographic data, pulmonary function test results, the 6-minute walk distance (6MWD), the gender-age-physiology (GAP) index score, dyspnea severity (modified Medical Research Council, mMRC), and fatigue severity (Multidimensional Fatigue Inventory, MFI-20) were recorded. Results: Thirty-five IPF patients (29 males, aged 65.7 ± 8.0 years) were included in the study (forced vital capacity (FVC)=77±16.2%, diffusing capacity for carbon monoxide (DLCO)=55.7±16.4%, 6MWD=398.4±88 m, GAP index=3.4±1.1 (18 stage 1, 17 stage 2). Patients with GAP stage 2 had lower step counts than those with GAP stage 1 (3325.1±2253 steps vs. 7892±3132 steps, p<0.001). The time spent in moderate to vigorous physical activity (MVPA, defined as the time spent in activities ≥3.0 METs) was significantly shorter in GAP stage 2 patients than in GAP stage 1 patients (7 minutes [IQR: 1.5–18.5] vs 56 minutes [IQR: 30.5–139.5], p<0.001). The step count and GAP index score (Rs=-0.716, p<0.001), age (Rs=-0.381, p=0.024), FVC (Rs=0.443, p=0.008), DLCO (Rs=0.715, p<0.001), 6MWD (Rs=0.833, p<0.001), MFI-20 score (Rs=-0.783, p<0.001), and mMRC score (Rs=-0.833, p<0.001) were correlated. Multiple regression analysis revealed that the step count was independently associated with the 6MWD (p=0.005) and MFI-20 score (p=0.014). The MVPA time was correlated with the GAP index score (Rs=-0.810, p<0.001), age (Rs=-0.427, p=0.010), FVC (Rs=0.490 p=0.003), DLCO (Rs=0.736, p<0.001), 6MWD (Rs=0.809, p<0.001), MFI-20 score (Rs=-0.830, p<0.001) and mMRC score (Rs=-0.826, p<0.001). Multiple regression analysis revealed that the MVPA time was independently associated with the GAP index score (p=0.007). Conclusions: The physical activity parameters of IPF patients were associated with prognostic markers such as the GAP index score, pulmonary function parameters and the 6MWD.