Impact of Topiramate on Rat Phrenic Nerve-Hemidiaphragm Preparations

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Kucukali C. I., Tuzun E., NURTEN A.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.54, no.3, pp.202-204, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 54 Issue: 3
• Publication Date: 2017
• Doi Number: 10.5152/npa.2017.19422
• Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.202-204
• Istanbul University Affiliated: Yes

Abstract

Introduction: Topiramate has a negative modulatory effect on voltage-gated ion channels involved in neuromuscular junction transmission. To investigate the potential impact of topiramate on muscle contraction, phrenic nerve-hemidiaphragm preparations were used as a neuromuscular junction model.