Bimodal Pattern of Coronary Microvascular Involvement in Diabetes Mellitus

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Sezer M., Kocaaga M., Aslanger E., Atici A., Demirkiran A., Bugra Z., ...More

JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.5, no.11, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 5 Issue: 11
• Publication Date: 2016
• Doi Number: 10.1161/jaha.116.003995
• Journal Name: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Istanbul University Affiliated: Yes

Abstract

Background-The contribution of functionally disturbed coronary autoregulation and structurally impaired microvascular vasodilatory function to reduced coronary flow velocity reserve, reflecting impaired coronary microcirculation in diabetes mellitus (DM), has not been clearly elucidated. The objective of this study was to identify the mechanism of coronary microvascular impairment in DM in relation to duration of disease.